Assigning Non-Hydrogen Counts

The non-hydrogen count is the number of non-hydrogen atoms attached to a specific atom (node). Existing connections are considered (e.g., every carbon atom in a cyclohexane ring has a non-hydrogen attachment count of 2, specifically 2 Ring non-hydrogen attachments.)

You can allow for or force substitution in a CSS (closed substructure search) or SSS (substructure search) by altering the non-hydrogen count of one or more atom nodes.

In the query structure below, the blue highlighted node is connected to two other carbon atoms with ring attachments, so its non-hydrogen count is Ring: 2. Note: A node's bond value does not contribute to the non-hydrogen count value (e.g., the blue-highlighted node has one single and one double bond, but the non-hydrogen value is still Ring: 2.)

If we right-click on the node, click Non-Hydrogen Count, and then set the count to a minimum of Ring/Chain: 2, we will also be able to retrieve substances with a substituent at this position.

Note: This value should not contradict (and therefore must include) the number and type of connections drawn in the structure query.

Learn More

Drawing and Editing Structures

Drawing Substructure Queries

Drawing Reaction Queries